A homozygous p.Leu813Pro gain-of-function NLRP1 variant causes phenotypes of different severity in two siblings
Li MF, Lay K, Zimmer A, Technau-Hafsi K, Wong J, Reimer-Taschenbrecker A, Rohr J, Abdalla E, Fischer J, Reversade B, Has C (2023). British Journal of Dermatology 188(2), 259-267 

 

DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling
Harapas CR*, Robinson KS*, Lay K*, Wong J, Moreno Traspas R, Nabavizadeh N, Rass-Rothschild A, Boisson B, Drutman SB, Laohamonthonkul P, Bonner D, Xiong JR, Gorrell MD, Davidson S, Yu C-H, Fleming MD, Gudera J, Stein J, Ben-Harosh M, Groopman E, Shimamura A, Tamary H, Kayserili H, Hatipoğlu N, Casanova J-L, Bernstein JA, Zhong FL, Masters SL & Reversade B (2022). Science Immunology 7, eabi4611 (*co-first authors)

 

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells
Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, Paillette P, Valadão A-LC, Robinson KS, Bastard P, Lam N, Fadrique R, Rossi I, Pericat D, Bagayoko S, Leon-Icaza SA, Rombouts Y, Perouzel E, Tiraby M, COVID Human Genetic Effort, Zhang Q, Cicuta P, Jouanguy E, Neyrolles O, Bryant CE, Floto AR, Goujon C, Lei FZ, Martin-Blondel G, Silva S, Casanova J-L, Cougoule C, Reversade B, Marcoux J, Ravet E & Meunier E (2022). Molecular Cell 82, 2385–2400.e9

 

Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories
Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, Infarinato NR, Nikolova M, Luo S, Liu S, Novak JSS, Lay K, Pasolli HA & Fuchs E (2021). Science 374, eabh2444

 

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B and Wu B (2021). Nature Communications 12(1): 188

 

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia
Robinson KS, Teo DET, Tan KS, Toh GA, Ong HH, Lim CK, Lay K, Au BV, Lew TS, Chu JJH, Chow VTK, Wang Y, Zhong FL, and Reversade B (2020). Science 370(6521)

 

Stem cells repurpose proliferation to contain a breach in their niche barrier
Lay K, Yuan S, Gur-Cohen S, Miao Y, Han T, Naik S, Pasolli HA, Larsen SB and Fuchs E (2018). eLife 7:e41661

 

FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

Lay K, Kume T and Fuchs E (2016). Proceedings of the National Academy of Sciences of the United States of America 113(11), E1506-1515

 

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators
Lien WH, Polak L, Lin M, Lay K, Zheng D and Fuchs E (2014). Nature Cell Biology 16(2), 179-190